Healthwise® Amino Activate

All amino acids are bioavailable, but some are more bioavailable than others. There are some accredited studies on amino acids and brain chemistry but these are few, but what we do know is there are challenges preventing a single or combination of amino acids from reaching their full therapeutic potential, especially those that influence neurotransmitter production. Amino acids are limited in their ability to passively pass through the BBB due to the selective nature of the membrane.

The most successful group of amino acids to cross the BBB is the N Acetyl group as they are membrane permeable and hydrophobic so will not easily dissolve in body fluids. To aid the uptake of L form amino acids, a shuttle is needed, which is usually in carbohydrate form. Additionally, hepatic absorption of amino acids is a large challenge to those over 65 as intestinal absorption of amino acids decline after this age.

The use of the N Acetyl form of amino acids is more well absorbed in the elderly, but the use of a specific shuttle, such as HW Amino Activate, to facilitate L group absorption may also be used for amino acids such as Tryptophan, Tyrosine, Glutamine and GABA, for example.

The ingredients in Amino Activate target both the cell membrane and BBB.

GLYCINE .. CNS TRANSMITTER
Glycine is the smallest non-essential, neutral and metabolically inert amino acid with excellent absorption. It is an essential substrate for the synthesis of several biologically important biomolecules and compounds and participates in the synthesis of proteins, the production of the tripeptide glutathione and in detoxification reactions. Additionally, Glycine has a sweet taste which makes it the ideal base for compounding and incorporation into any formula.

COCONUT WATER >> CARBOHYDRTE SHUTTLE
Coconut water is high in minerals such as potassium and magnesium which further facilitate the absorption of amino acids as well as being an excellent carbohydrate source .

MSM >> CELL BIOAVAILABILITY
Methylsulfonylmethane (MSM) Research has shown that Methylsulfonylmethane (MSM) can improve the permeability and fluidity of cell membranes, which can enhance the ability of cells to absorb nutrients and eliminate wastes. Cell membranes are made up of a double layer of phospholipids that provide a barrier around the cell, protecting it from the external environment and certain substances. The sulfur component of MSM can initiate the opening of these pathways.

VITAMIN C >> ANTIOXIDANT
Vitamin C reduces the chance of amino acids oxidizing Vitamin C plays a crucial role in amino acid synthesis as it catalyzes the post-translational hydroxylation of proline and lysine residues. Vitamin C is also involved in other physiological functions such as cholesterol biosynthesis and serotonin synthesis. In vivo, vitamin C acts as a cofactor for numerous biosynthetic enzymes required for the synthesis of amino acid-derived macromolecules, neurotransmitters, and neuropeptide hormones, and is also a cofactor for various hydroxylases involved in the regulation of gene transcription and epigenetics.

1 level metric teaspoon (4000mg) of Amino Activate contains:

SERVING SUGGESTION: Add 1/2 to 1 level teaspoon with your HealthWise® Amino Acid of choice. Mix well in water or juice until dissolved. Best taken between meals.